Be Still My Heart (Solution)

ACROSS
7. decreased muscle function in hypertrophic and restrictive cardiomyopathy: compliance

11. blood pooling in extra-cardiac organs in heart failure: congestion

12. group at greatest risk of sudden death in hypertrophic cardiomyopathy: athletes

13. target of gene mutations in hypertrophic cardiomyopathy: sarcomere

15. amyloid cardiomyopathy is an example of restrictive cardiomyopathy

16. degeneration of leaflet in mitral valve prolapse: myxoid

19. best imaging modality to dx. hypertrophic cardiomyopathy: ECHO

21. amyloid protein structure that results in tissue deposition (3 words): beta pleated sheet

24. likely cause of sudden death in hypertrophic cardiomyopathy and mitral valve prolapse: arrhythmia

27. protein implicated in dilated cardiomyopathy: dystrophin

28. tract obstructed in hypertrophic cardiomyopathy: outflow

30. stenosis of a heart valve leads to an increased pressure gradient across the valve

DOWN
1. cardiac syndrome with long face, torso, arms and fingers: Marfan syndrome

2. type of calcification in calcific stenosis of normal aortic valve in old age: senile

3. fluid accumulation in extra-cardiac organs in heart failure: edema

4. protein with gene mutation in patients with Marfan Syndrome: fibrillin

5. heard on auscultation in mitral valve prolapse: click

6. location of myocardial lesion in hypertrophic cardiomyopathy: septum

8. middle wall in bicuspid aortic valve (2 words): median raphe

9. gross pattern of physiologic hypertrophy: concentric

10. type of calcification in calcific stenosis of bicuspid valve: dystrophic

14. heart weight over 400 grams in an adult: cardiomegaly

17. scattering of light at two different angles by amyloid proteins: birefringence

18. decreased muscle function in dilated cardiomyopathy: contractility

19. gross appearance of hypertrophic cardiomyopathy: eccentric

20. myocardial response to pressure overload: hypertrophy

22. heart shape in dilated cardiomyopathy: globoid

23. myocardial response to volume overload: dilation

25. abnormal myocyte pattern in hypertrophic cardiomyopathy; disarray

26. consistency of prolapsed mitral valve: floppy

29. myocardial consistency in dilated cardiomyopathy: flabby

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Be Still My Heart (Pathology of Sudden Death and Heart Failure)