Be Still My Heart (Pathology of Sudden Death and Heart Failure)

Be Still My Heart (Pathology of Sudden Death and Heart Failure)
Sudden death and heart failure are the final common pathways for all cardiac diseases. Diseases as apparently divergent as aortic stenosis and cardiac amyloid can share a final common pathway. How many pathologic features of sudden death and heart failure can you identify? If you need help, just click the Hint link to see a gross or microscopic image related to the clue.



 

ACROSS
7. decreased muscle function in hypertrophic and restrictive cardiomyopathy

11. blood pooling in extra-cardiac organs in heart failure

12. group at greatest risk of sudden death in hypertrophic cardiomyopathy Hint (BSMYA12)

13. target of gene mutations in hypertrophic cardiomyopathy Hint (BSMYA13)

15. amyloid cardiomyopathy is an example of _______ cardiomyopathy Hint (BSMYA15)

16. degeneration of leaflet in mitral valve prolapse Hint (BSMYA16)

19. best imaging modality to dx. hypertrophic cardiomyopathy

21. amyloid protein structure that results in tissue deposition (3 words)

24. likely cause of sudden death in hypertrophic cardiomyopathy and mitral valve prolapse Hint (BSMYA24)

27. protein implicated in dilated cardiomyopathy

28. tract obstructed in hypertrophic cardiomyopathy

30. stenosis of a heart valve leads to an increased pressure _______ across the valve

DOWN
1. cardiac syndrome with long face, torso, arms and fingers Hint (BSMYD1)

2. type of calcification in calcific stenosis of normal aortic valve in old age

3. fluid accumulation in extra-cardiac organs in heart failure Hint (BSMYD3)

4. protein with gene mutation in patients with Marfan Syndrome

5. heard on auscultation in mitral valve prolapse

6. location of myocardial lesion in hypertrophic cardiomyopathy

8. middle wall in bicuspid aortic valve (2 words)

9. gross appearance of physiologic hypertrophy

10. type of calcification in calcific stenosis of bicuspid valve

14. heart weight over 400 grams

17. scattering of light at two different angles by amyloid proteins

18. decreased muscle function in dilated cardiomyopathy

19. gross appearance hypertrophic cardiomyopathy

20. myocardial response to pressure overload

22. heart shape in dilated cardiomyopathy Hint (BTMYD22)

23. myocardial response to volume overload

25. abnormal myocyte pattern in hypertrophic cardiomyopathy  Hint (BSMYD25)

26. consistency of prolapsed mitral valve

29. myocardial consistency in dilated cardiomyopathy 

SOLUTION
Be Still My Heart (Solution)